2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrate hydrochloride
Linocaine hydrochloride
CAS: 6108-05-0
Molecular Formula: C14H25ClN2O2
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrate hydrochloride - Names and Identifiers
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrate hydrochloride - Physico-chemical Properties
| Molecular Formula | C14H25ClN2O2 |
| Molar Mass | 288.81 |
| Melting Point | 75-79℃ |
| Water Solubility | Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether. |
| Solubility | H2O: soluble |
| Appearance | solid |
| Color | white |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Physical and chemical properties of white crystals, odorless, taste slightly bitter and hemp. Very soluble in water, ethanol and organic solvents, but insoluble in ether. Aqueous solution in the case of acid, alkali does not decompose, repeated high-pressure sterilization rarely deterioration. |
| Use | Uses lidocaine hydrochloride is an amide local anesthetic. After blood absorption or intravenous administration, the central nervous system has obvious excitation and inhibition of biphasic effect, and can be no precursor of excitation, low blood concentration, analgesia and drowsiness, pain threshold increased; With the increase of dose, the effect or toxicity increased, and the blood concentration of the sub-Middle toxin had anticonvulsant effect. |
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrate hydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | AN7700000 |
| TSCA | Yes |
| HS Code | 2924296000 |
| Hazard Class | 6.1 |
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrate hydrochloride - Progress in analysis of lidocaine hydrochloride
from VIP Journal Professional Edition
Author:
Abstract:
lidocaine hydrochloride is a commonly used local anesthetic and antiarrhythmic drug. In this paper, the Volume Analysis, spectrophotometric analysis, chromatographic analysis of lidocaine pharmaceutical preparations, as well as serum and plasma sample pretreatment and high performance thin layer chromatography, high performance liquid chromatography and micellar electrokinetic capillary electrophoresis, hope to provide reference for future research.
Key words:
lidocaine hydrochloride; Content determination; Sample pretreatment; Chromatography; spectroscopy
DOI:
CNKI:SUN:YWFX.0.2011-01-060
cited:
year:
2011
Last Update：2024-01-02 23:10:35
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrate hydrochloride - Determination of lidocaine hydrochloride in different media by spectrophotometry
from hownet
Author:
Qin Zhen hui , Shen Guang-ming , Tan Rong Puli army
Abstract:
Objective: to establish a method for the determination of lidocaine hydrochloride in different media. Methods: The principle of the method is that lidocaine hydrochloride reacts with bromocresol purple dye to form ion association complex. The absorbance of lidocaine hydrochloride was determined by ultraviolet spectrophotometry at 588,426nm wavelength, and the content was calculated. Results: at 588,426nm wavelength. The concentration of lidocaine hydrochloride in the range of 2.76 × 10 ^-6~2.83 × 10 ^-5, beer's law is obeyed in the range of 5.64 × 10 ^-6~2.48 × 10 ^-5mol · L ^-1, and the apparent molar absorptivity is 1.45 × 10 ^ 4,7.11 × 10 ^ 3L · mol ^-1 · cm ^-1, with detection limits of 8.37 × 10 ^-7 and 1.71 × 10 ^-6mol · L, respectively. Conclusion: the established method is sensitive, selective, safe and reliable, and can be used for the determination of lidocaine hydrochloride in different preparations, human plasma and urine.Key words:
spectrophotometry lidocaine hydrochloride content
DOI:
10.3969/j.issn.1001-0408.2007.34.022
cited:
year:
2007
Last Update：2023-08-16 22:09:50
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